论文标题
使用系统动力学和游戏理论对整个基因组测序实施进行建模
Modeling of Whole Genomic Sequencing Implementation using System Dynamics and Game Theory
论文作者
论文摘要
生物标志物测试是一种肿瘤学实验室测试，用于选择靶向癌症治疗并有助于避免无效治疗。存在几种类型的生物标志物测试，可用于检测基因表达中特定突变或变异的存在。整个基因组测序（WGS）是用于分析整个基因组的生物标志物测试。 WGS可以提供更全面的诊断信息，但也比其他测试更昂贵。在这项研究中，采用系统动力学和游戏理论模型来评估场景，并促进有关WGS实施的组织决策。这些模型评估了WGS的临床和经济价值及其可及性和可访问性。评估的方案涵盖了使用时间诊断和总成本实施WGS的时间。
Biomarker testing is a laboratory test in oncology that is used in the selection of targeted cancer treatments and helping to avoid ineffective treatments. There exist several types of biomarker tests that can be used to detect the presence of particular mutations or variation in gene expression. Whole Genome Sequencing (WGS) is a biomarker test for analyzing the entire genome. WGS can provide more comprehensive diagnostic information, but it is also more expensive than other tests. In this study, System Dynamics and Game Theoretic models are employed to evaluate scenarios, and facilitate organizational decision making regarding WGS implementation. These models evaluate the clinical and economic value of WGS as well as its affordability and accessibility. The evaluated scenarios have covered the timing of implementing WGS using time to diagnosis and total cost.
