论文标题
对双层骨料微结构的评论决定了C.O.肺表面活性剂悬浮剂的粘弹性。 Ciutara和J.A. Zasadzinski，软物质，2021，17，5170-5182
Comment on Bilayer aggregate microstructure determines viscoelasticity of lung surfactant suspensions by C.O. Ciutara and J.A. Zasadzinski, Soft Matter, 2021, 17, 5170-5182
论文作者
论文摘要
对于将肺表面活性剂递送到肺部的应用，现有的临床制剂的流变问题至关重要。最近，Ciutara和Zasadsinky（软物质，2021，17，5170-5182）测量了Infasurf，Survanta和Curosurf的流变特性，这是最常用的三种肺表面活性剂替代物。这项研究表明，这些液体是剪切的，并以屈服应力为特征。 Ciutara等人获得的结果。关于Curosurf与我们在胶体和表面B：Biointerfaces中发表的结果不同，2019，178，337-345和ACS NANO，2020，14，466-475。相反，我们发现Curosurf悬架是粘性的牛顿或略微剪切的流体或少薄薄的均无作用的应力。该评论的目的是讨论两项研究之间差异的可能原因，并建议对于诸如表面活性剂替代品之类的生物流体，旋转磁光谱（MRS）的微流变技术可以提供有价值的结果。
For applications of pulmonary surfactant delivery to the lungs, the question of rheology of the existing clinical formulations is of upmost importance. Recently, Ciutara and Zasadsinky (Soft Matter, 2021, 17, 5170-5182) measured the rheological properties of Infasurf, Survanta and Curosurf, three of the most used pulmonary surfactant substitutes. This study revealed that these fluids are shear-thinning and characterized by a yield stress. The results obtained by Ciutara et al. on Curosurf differ from our results published in Colloids and Surfaces B: Biointerfaces, 2019, 178, 337-345 and in ACS Nano, 2020, 14, 466 - 475. In contrast, we found that Curosurf suspensions are viscous Newtonian or slightly shear-thinning fluids, with no evidence of yield stress. The purpose of this Comment is to discuss possible causes for the discrepancy between the two studies, and to suggest that for biological fluids such as surfactant substitutes, the microrheology technique of rotational magnetic spectroscopy (MRS) can provide valuable results.
