论文标题
具有表面移动DNA接头的动力学上有限的胶体颗粒价
Kinetically limited valence of colloidal particles with surface mobile DNA linkers
论文作者
论文摘要
我们表征了在动力学有限的价条件下，胶体颗粒与表面移动DNA接头的自组装。为此，我们提出了一个计算机仿真模型，该模型可定量地捕获有关这些系统的主要动态过程之间的相互作用，并允许在实验中对长时间尺度进行仿真。该模型通过直接比较可用的实验结果来验证，该模型显示了总体良好的一致性，其中包括对平均有效价的测量及其概率分布与颗粒表面DNA接头密度的函数的函数。最后，模拟结果用于证明颗粒密度和特征DNA杂交时间对有效价的相反影响。
We characterize the self-assembly of colloidal particles with surface mobile DNA linkers under kinetically limited valence conditions. For this, we put forward a computer simulation model that captures quantitatively the interplay between the main dynamic processes governing these systems and allows the simulation of the long time scales reached in experiments. The model is validated by direct comparison with available experimental results, showing an overall good agreement that includes measurements of the average effective valence and its probability distribution as a function of the density of DNA linkers on the particles surface. Finally, simulation results are used to evidence the opposite impact of particle density and characteristic DNA hybridization time on the effective valence.
