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This paper presents a machine learning methodology to improve the predictions of traditional RANS turbulence models in channel flows subject to strong variations in their thermophysical properties. The developed formulation contains several improvements over the existing Field Inversion Machine Learning (FIML) frameworks described in the literature, as well as the derivation of a new modelling technique. We first showcase the use of efficient optimization routines to automatize the process of field inversion in the context of CFD, combined with the use of symbolic algebra solvers to generate sparse-efficient algebraic formulas to comply with the discrete adjoint method. The proposed neural network architecture is characterized by the use of an initial layer of logarithmic neurons followed by hyperbolic tangent neurons, which proves numerically stable. The machine learning predictions are then corrected using a novel weighted relaxation factor methodology, that recovers valuable information from otherwise spurious predictions. The study uses the K-fold cross-validation technique, which is beneficial for small datasets. The results show that the machine learning model acts as an excellent non-linear interpolator for DNS cases well-represented in the training set, and that moderate improvement margins are obtained for sparser DNS cases. It is concluded that the developed machine learning methodology corresponds to a valid alternative to improve RANS turbulence models in flows with strong variations in their thermophysical properties without introducing prior modeling assumptions into the system.