论文标题
反应引起的分子舞和酶的增强
Reaction-induced molecular dancing and boosted diffusion of enzymes
论文作者
论文摘要
提出和分析了反应诱导的活性分子运动的一种新型机制，不涉及任何形式的自我推测。 Because of the momentum exchange with the surrounding solvent, conformational transitions in mechano-chemical enzymes are accompanied by motions of their centers of mass. As we show, in combination with rotational diffusion, such repeated reciprocal motions generate an additional random walk - or molecular dancing - and hence boost translational diffusion of an enzyme.开发了这种现象的系统理论，以示例为例，一种刚性两态哑铃的简单酶模型。为了支持分析，进行了数值模拟。我们的结论是，分子舞的现象可以是反应引起的酶扩散增强的观察结果。这样的主要实验发现，例如飞跃的发生，抗疗法，线性依赖于反应转移速率和能源供应速率，因此被解释了。此外，在自然和合成的其他系统中也可以进行舞蹈行为。将来，可以使用这种影响来开发有趣的生物技术应用。
A novel mechanism of reaction-induced active molecular motion, not involving any kind of self-propulsion, is proposed and analyzed. Because of the momentum exchange with the surrounding solvent, conformational transitions in mechano-chemical enzymes are accompanied by motions of their centers of mass. As we show, in combination with rotational diffusion, such repeated reciprocal motions generate an additional random walk - or molecular dancing - and hence boost translational diffusion of an enzyme. A systematic theory of this phenomenon is developed, using as an example a simple enzyme model of a rigid two-state dumbbell. To support the analysis, numerical simulations are performed. Our conclusion is that the phenomenon of molecular dancing could underlie the observations of reaction-induced diffusion enhancement in enzymes. Major experimental findings, such as the occurrence of leaps, the anti-chemotaxis, the linear dependence on the reaction turnover rate and on the rate of energy supply, become thus explained. Moreover, the dancing behavior is possible in other systems, natural and synthetic, too. In the future, interesting biotechnology applications may be developed using such effects.
