论文标题
多任务学习改善了从Cine致密MRI的心脏的晚期机械激活检测
Multitask Learning for Improved Late Mechanical Activation Detection of Heart from Cine DENSE MRI
论文作者
论文摘要
理想的无疤痕和晚期激活的最佳起搏部位的选择对于心脏重新同步治疗(CRT)的反应至关重要。尽管目前的方法成功地检测了这种晚期机械激活(LMA)区域作为激活时间回归的问题,但其准确性仍然不令人满意,尤其是在存在心肌疤痕的情况下。为了解决这个问题,本文介绍了一个多任务深度学习框架,该框架同时估算了LMA量,并根据CINE位移进行了用刺激的回声(密度)磁共振成像(MRI)对无疤痕的LMA区域进行分类。通过新引入的辅助LMA区域分类子网络,我们提出的模型通过心肌疤痕显示出对复杂模式原因的更强性,从而显着消除了其在LMA检测中的负面影响,进而改善了疤痕分类的性能。为了评估我们方法的有效性,我们在实际心脏MR图像上测试模型,并将预测的LMA与最新方法进行比较。它表明我们的方法实现了大幅提高的精度。此外,我们采用梯度加权类激活映射(Grad-CAM)来可视化所有方法所学的特征图。实验结果表明,我们提出的模型更好地识别了LMA区域模式。
The selection of an optimal pacing site, which is ideally scar-free and late activated, is critical to the response of cardiac resynchronization therapy (CRT). Despite the success of current approaches formulating the detection of such late mechanical activation (LMA) regions as a problem of activation time regression, their accuracy remains unsatisfactory, particularly in cases where myocardial scar exists. To address this issue, this paper introduces a multi-task deep learning framework that simultaneously estimates LMA amount and classify the scar-free LMA regions based on cine displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI). With a newly introduced auxiliary LMA region classification sub-network, our proposed model shows more robustness to the complex pattern cause by myocardial scar, significantly eliminates their negative effects in LMA detection, and in turn improves the performance of scar classification. To evaluate the effectiveness of our method, we tests our model on real cardiac MR images and compare the predicted LMA with the state-of-the-art approaches. It shows that our approach achieves substantially increased accuracy. In addition, we employ the gradient-weighted class activation mapping (Grad-CAM) to visualize the feature maps learned by all methods. Experimental results suggest that our proposed model better recognizes the LMA region pattern.