论文标题
人神经元的结构衰老与精神分裂症的变化相反
Structural aging of human neurons is the opposite of the changes in schizophrenia
论文作者
论文摘要
人类心态随着年龄的增长而发展，并且在精神疾病中发生了改变，尽管其潜在机制尚不清楚。在这项研究中，我们分析了从八种精神分裂症和八个对照病例的前扣带回皮层的脑部组织脑组织的纳米尺度三维结构。控制病例的神经突曲率的分布谱图取决于其年龄，导致神经突曲率的标准偏差与年龄相关（Pearson的R = -0.80，P = 0.018）。与对照病例相反，精神分裂症病例与这种相关性偏离，与对照组相比，神经突曲率高60％（p = 7.8 x 10^（ - 4））。神经突曲率还显示出与幻觉评分（Pearson的r = 0.80，p = 1.8 x 10^（ - 4））的相关性，表明神经突结构与脑功能有关。我们建议神经突曲率在大脑衰老中起关键作用，可以用作利用精神分裂症的新型治疗方法的标志。该纳米CT论文是我们长达十年分析的结果，并且在病例数方面是前所未有的。
Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls (p = 7.8 x 10^(-4)). The neurite curvature also showed a correlation with a hallucination score (Pearson's r = 0.80, p = 1.8 x 10^(-4)), indicating that neurite structure is relevant to brain function. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia. This nano-CT paper is the result of our decade-long analysis and is unprecedented in terms of number of cases.
