论文标题
细胞质和扩散运输在形态梯度建立中的作用
The Role of Cytonemes and Diffusive Transport in the Establishment of Morphogen Gradients
论文作者
论文摘要
形态剂的空间分布提供位置信息 开发系统，但如何建立和维护分布 仍然是一个开放的问题。通过扩散运输是 传统机制，但最近的实验工作表明细胞可以 也通过称为菌卵形的结构进行交流，称为cytonemes 细胞间触点。在这里，我们调查每个可能扮演的角色 单独在复杂的组织中，以及它们如何共同建立可靠的 形态学的空间分布。
Spatial distributions of morphogens provide positional information in developing systems, but how the distributions are established and maintained remains an open problem. Transport by diffusion has been the traditional mechanism, but recent experimental work has shown that cells can also communicate by filopodia-like structures called cytonemes that make direct cell-to-cell contacts. Here we investigate the roles each may play individually in a complex tissue and how they can jointly establish a reliable spatial distribution of a morphogen.
