论文标题
压缩不稳定性使细胞诱导的极端致密化模式在纤维外基质中：离散模型预测
Compressive Instabilities Enable Cell-Induced Extreme Densification Patterns in the Fibrous Extracellular Matrix: Discrete Model Predictions
论文作者
论文摘要
通过建模和模拟，我们表明材料不稳定性在纤维胶原细胞外基质（ECM）的机械行为中起主要作用，如收缩生物学细胞变形时所观察到的那样。我们比较了两个纤维网络模型的家族，即稳定和家族2的家族，以及在压缩中的单个纤维的不稳定力伸展反应。后者是具有分层结构的光束后弯曲的特征。我们的模拟显示了每个家庭的不同压缩不稳定性，即家庭2中的纤维崩溃（屈曲）和家庭中的纤维元素崩溃（snap through）1。这些结果导致高度局部的致密性区域，这些致密纤维由从单个收缩细胞中散发出的强度结实的纤维或在实验中加入相邻的细胞，这些纤维由单个收缩细胞或加入相邻的细胞中。尽管这两个家族的反应存在很大差异，但我们的工作强调了屈曲/压缩不稳定性在纤维生物组织的行为中的重要性，这对癌症的侵袭和转移有影响。
Through modelling and simulations we show that material instabilities play a dominant role in the mechanical behavior of the fibrous collagen Extracellular Matrix (ECM), as observed when the ECM is deformed by contractile biological cells. We compare two families of fiber network models, Family 1 with stable and Family 2 with unstable force-stretch response of individual fibers in compression. The latter is a characteristic of post-buckling of beams with hierarchical structure. Our simulations reveal different compression instabilities at play in each family, namely, fiber collapse (buckling) in Family 2 and fiber element collapse (snap-through) in Family 1. These result in highly localized densification zones consisting of strongly aligned fibers emanating from individual contractile cells or joining neighbouring cells, as observed in experiments. Despite substantial differences in the response of the two families, our work underscores the importance of buckling/compression instabilities in the behavior of fibrous biological tissues, with implications in cancer invasion and metastasis.
