论文标题

单X射线暗场成像:使用单网格设置量化样品微观结构

Single-exposure x-ray dark-field imaging: quantifying sample microstructure using a single-grid setup

论文作者

How, Ying Ying, Paganin, David M., Morgan, Kaye S.

论文摘要

X射线成像系统中最小可检测的样品特征的大小通常受系统的空间分辨率限制。现在,可以使用扩散的暗场信号克服此限制,该信号是由未解决的相位效应或未解决样品微结构的超小角X射线散射产生的。该暗场信号的定量度量可用于揭示微观结构的大小或用于医学诊断,安全筛查和材料科学的材料。最近,我们得出了一种使用基于单曝光网格的方法,以散射角度来量化扩散的暗场信号。在此手稿中,我们研究了从这个单曝光暗场信号中量化样品微结构大小的问题。我们通过量化由5种不同尺寸的聚苯乙烯微球产生的扩散的深色场信号,范围从1.0 $ $ m到10.8 $μ$ m,以研究深色场信号的强度随样品显微结构大小($ s $)而变化。我们还探索了使用简单的方程式进行单次曝光暗场成像的可行性,以给定具有特定尺寸和厚度的微观结构,并通过实验数据成功验证了此方程。我们的理论模型预测,暗场散射角与$ \ sqrt {s} $成反比,这与我们的实验数据一致。

The size of the smallest detectable sample feature in an x-ray imaging system is usually restricted by the spatial resolution of the system. This limitation can now be overcome using the diffusive dark-field signal, which is generated by unresolved phase effects or the ultra-small-angle x-ray scattering from unresolved sample microstructures. A quantitative measure of this dark-field signal can be useful in revealing the microstructure size or material for medical diagnosis, security screening and materials science. Recently, we derived a new method to quantify the diffusive dark-field signal in terms of a scattering angle using a single-exposure grid-based approach. In this manuscript, we look at the problem of quantifying the sample microstructure size from this single-exposure dark-field signal. We do this by quantifying the diffusive dark-field signal produced by 5 different sizes of polystyrene microspheres, ranging from 1.0 $μ$m to 10.8 $μ$m, to investigate how the strength of the dark-field signal changes with the sample microstructure size, $S$. We also explore the feasibility of performing single-exposure dark-field imaging with a simple equation for the optimal propagation distance given microstructure with a specific size and thickness, and successfully verify this equation with experimental data. Our theoretical model predicts that the dark-field scattering angle is inversely proportional to $\sqrt{S}$, which is consistent with our experimental data.

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