论文标题
生物热的转移和蒙特卡洛测量人脑的近红外经颅刺激
Bio-Heat Transfer and Monte Carlo Measurement of Near-Infrared Transcranial Stimulation of Human Brain
论文作者
论文摘要
经颅光生物调节是一种用于非侵入性脑刺激的光学方法。该方法通过600-1100 nm的头皮发射红色和近红外光，在1-20 J/CM2范围内投射低能。最近的研究对用药物疗法和侵入性脑刺激取代这种方法非常乐观。但是，对于光穿透深度和可能的热副作用而存在关注和歧义。虽然文献调查表明，在实验性光学脑刺激后，皮肤温度升高，但证据不足支持温度的安全升高或皮质中的光渗透量。因此，我们旨在对人脑近红外刺激的传热进行全面研究。我们的研究通过投影具有100 mW/cm2功率密度的810 nm光，以使用生物学转移和辐射传递方程来评估其热和光学效应，从而考虑了人脑模型上的经颅光生物调节。我们的结果证实，近红外光谱对温度的增量影响很小，大约穿透1 cm，达到皮层。还进行了对传热的时间变化研究，以测量光学刺激期间的温度变化。
Transcranial photobiomodulation is an optical method for non-invasive brain stimulation. The method projects red and near-infrared light through the scalp within 600-1100 nm and low energy within the 1-20 J/cm2 range. Recent studies have been optimistic about replacing this method with pharmacotherapy and invasive brain stimulation. However, concerns and ambiguities exist regarding the light penetration depth and possible thermal side effects. While the literature survey indicates that the skin temperature rises after experimental optical brain stimulation, inadequate evidence supports a safe increase in temperature or the amount of light penetration in the cortex. Therefore, we aimed to conduct a comprehensive study on the heat transfer of near-infrared stimulation for the human brain. Our research considers the transcranial photobiomodulation over the human brain model by projecting 810 nm light with 100 mW/cm2 power density to evaluate its thermal and optical effects using bioheat transfer and radiative transfer equation. Our results confirm that the near-infrared light spectrum has a small incremental impact on temperature and approximately penetrates 1 cm, reaching the cortex. A time-variant study of the heat transfer was also carried out to measure the temperature changes during optical stimulation.
