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There are two tensions related to the Cabibbo angle of the CKM matrix. First, the determinations of $V_{us}$ from $K_{μ2}$, $K_{\ell3}$, and $τ$ decays disagree at the $3σ$ level. Second, using the average of these results in combination with $β$ decays (including super-allowed $β$ decays and neutron decay), a deficit in first-row CKM unitarity with a significance of again about $3σ$ is found. These discrepancies, known as the Cabibbo Angle anomaly, can in principle be solved by modifications of $W$ boson couplings to quarks. However, due to $SU(2)_L$ invariance, $Z$ couplings to quarks are also modified and flavour changing neutral currents can occur. In order to consistently assess the agreement of a new physics hypothesis with data, we perform a combined analysis for all dimension-six Standard Model Effective Field Theory operators that generate modified $W$ couplings to first and second generation quarks. We then study models with vector-like quarks, which are prime candidates for a corresponding UV completion as they can affect $W$-quark couplings at tree level, and we perform a global fit including flavour observables (in particular loop effects in $ΔF=2$ processes). We find that the best fit can be obtained for the $SU(2)_L$ doublet vector-like quark $Q$ as it can generate right-handed $W$-$u$-$d$ and $W$-$u$-$s$ couplings as preferred by data.