论文标题

AI在药物发现中的作用:挑战,机遇和策略

The Role of AI in Drug Discovery: Challenges, Opportunities, and Strategies

论文作者

Blanco-Gonzalez, Alexandre, Cabezon, Alfonso, Seco-Gonzalez, Alejandro, Conde-Torres, Daniel, Antelo-Riveiro, Paula, Pineiro, Angel, Garcia-Fandino, Rebeca

论文摘要

人工智能(AI)有可能彻底改变药物发现过程,从而提高效率,准确性和速度。但是,AI的成功应用取决于高质量数据的可用性,道德问题的解决以及对基于AI的方法的局限性的识别。在本文中,审查了该领域中AI的好处,挑战和弊端,并提出了克服当前障碍的可能策略和方法。还讨论了数据增强,可解释的AI以及AI与传统实验方法的整合以及药物研究中AI的潜在优势的使用。总体而言,这篇评论强调了AI在药物发现中的潜力,并为实现其在该领域的潜力带来的挑战和机会提供了见解。 来自人类作者的注意:创建本文是为了测试基于GPT-3.5语言模型的聊天机器人Chatgpt的能力,以帮助人类作者撰写撰写评论文章。 AI生成的文本按照我们的说明(请参阅支持信息)作为起点,并评估了其自动生成内容的能力。经过彻底的审查后,人类作者实际上重写了手稿,努力在原始提案和科学标准之间保持平衡。在上一节中讨论了为此目的使用AI的优点和局限性。

Artificial intelligence (AI) has the potential to revolutionize the drug discovery process, offering improved efficiency, accuracy, and speed. However, the successful application of AI is dependent on the availability of high-quality data, the addressing of ethical concerns, and the recognition of the limitations of AI-based approaches. In this article, the benefits, challenges and drawbacks of AI in this field are reviewed, and possible strategies and approaches for overcoming the present obstacles are proposed. The use of data augmentation, explainable AI, and the integration of AI with traditional experimental methods, as well as the potential advantages of AI in pharmaceutical research are also discussed. Overall, this review highlights the potential of AI in drug discovery and provides insights into the challenges and opportunities for realizing its potential in this field. Note from the human-authors: This article was created to test the ability of ChatGPT, a chatbot based on the GPT-3.5 language model, to assist human authors in writing review articles. The text generated by the AI following our instructions (see Supporting Information) was used as a starting point, and its ability to automatically generate content was evaluated. After conducting a thorough review, human authors practically rewrote the manuscript, striving to maintain a balance between the original proposal and scientific criteria. The advantages and limitations of using AI for this purpose are discussed in the last section.

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