论文标题
衰老和阿尔茨海默氏病的代谢组学：从单词到多派
Metabolomics of Aging and Alzheimer's Disease: From Single-Omics to Multi-Omics
论文作者
论文摘要
衰老是一个多因素过程，也是发病率和死亡率的关键因素。阿尔茨海默氏病（AD）是一种与年龄有关的疾病，是全球残疾的主要原因。衰老和AD都可以通过代谢功能障碍来表征。代谢组学可以在研究样品中量化完整的代谢产物集，有助于研究衰老和AD的代谢改变。在这篇综述中，我们总结了有关衰老和AD的代谢组变化，讨论其生物学功能，并强调其作为诊断生物标志物或治疗靶标的潜在应用。还审查了多态方法的最新进展，以理解衰老和AD的代谢机制。
Aging is a multifactorial process and a key factor of morbidity and mortality. Alzheimer's disease (AD) is an age-related disorder and a main cause of worldwide disability. Both aging and AD can be characterized by metabolic dysfunction. Metabolomics can quantify the complete set of metabolites in a studied sample and is helpful for studying metabolic alterations in aging and AD. In this review, we summarize the metabolomic changes regarding aging and AD, discuss their biological functions, and highlight their potential application as diagnostic biomarkers or therapeutic targets. Recent advances in multi-omics approaches for understanding the metabolic mechanism of aging and AD are also reviewed.
