论文标题
生化系统中对称性破坏的通用热力学界限
Universal thermodynamic bounds on symmetry breaking in biochemical systems
论文作者
论文摘要
通过外部驱动力使生活系统保持不平衡。在平稳性时，它们表现出紧急的选择现象，这些现象破坏了平衡对称性，并源于由于非平衡条件而引起的可访问化学空间的扩展。在这里，我们使用矩阵定理在生化系统中这些破坏对称性特征的普遍热力学界限。我们的界限独立于动力学，并为封闭反应网络和开放反应网络持有。我们还将结果扩展到化学空间中的主方程。使用我们的框架，我们在动力学校对中恢复热力学约束。最后，我们表明，反应扩散模式的对比度只能通过非平衡驱动力来界定。我们的结果为理解非平衡条件在塑造生化系统的稳态特性中的作用提供了一个一般框架。
Living systems are maintained out-of-equilibrium by external driving forces. At stationarity, they exhibit emergent selection phenomena that break equilibrium symmetries and originate from the expansion of the accessible chemical space due to non-equilibrium conditions. Here, we use the matrix-tree theorem to derive universal thermodynamic bounds on these symmetry-breaking features in biochemical systems. Our bounds are independent of the kinetics and hold for both closed and open reaction networks. We also extend our results to master equations in the chemical space. Using our framework, we recover the thermodynamic constraints in kinetic proofreading. Finally, we show that the contrast of reaction-diffusion patterns can be bounded only by the non-equilibrium driving force. Our results provide a general framework for understanding the role of non-equilibrium conditions in shaping the steady-state properties of biochemical systems.
